Concurrent allergy and helminthiasis in underprivileged urban South African adults previously residing in rural areas
SOURCE: Parasite Immunology
OUTPUT TYPE: Journal Article
PUBLICATION YEAR: 2022
TITLE AUTHOR(S): Z-L.Mkhize-Kwitshana, P.Naidoo, N.M.Nkwanyana, M.L.H.Mabaso
KEYWORDS: ADULTS, GEOHELMINTH INFECTIONS, RURAL COMMUNITIES
DEPARTMENT: Public Health, Societies and Belonging (HSC)
Print: HSRC Library: shelf number 9812324
HANDLE: 20.500.11910/19378
URI: http://hdl.handle.net/20.500.11910/19378
OUTPUT TYPE: Journal Article
PUBLICATION YEAR: 2022
TITLE AUTHOR(S): Z-L.Mkhize-Kwitshana, P.Naidoo, N.M.Nkwanyana, M.L.H.Mabaso
KEYWORDS: ADULTS, GEOHELMINTH INFECTIONS, RURAL COMMUNITIES
DEPARTMENT: Public Health, Societies and Belonging (HSC)
Print: HSRC Library: shelf number 9812324
HANDLE: 20.500.11910/19378
URI: http://hdl.handle.net/20.500.11910/19378
If you would like to obtain a copy of this Research Output, please contact Hanlie Baudin at researchoutputs@hsrc.ac.za.
Abstract
This study investigated whether prior exposure to helminths (Ascaris IgE, Ascaris eggs and Trichuris eggs) either in childhood or in adulthood, and residence in rural and resource-limited urban areas influence allergy outcomes (asthma, rhinitis, IgE atopy and food allergy) in a South African population. Participants historical and present allergies data were collected through questionnaires and clinical record files. Coproscopy and immunoassays (ImmunoCAPTM Phadiatop, total IgE and allergen-specific fx3 IgE immunoassays and Ascaris IgE radioallergosorbent [RAST] tests) were used for active helminthiasis and allergy screens respectively. Data were analysed using logistic regression analysis, and models were adjusted for age, gender and locality. High Ascaris IgE was significantly associated with asthma (adjusted odds ratio [aOR] = 2.20, p = .047), IgE atopy (aOR = 18.18, p < .0001) and food allergy (aOR = 14.47, p < .0001). Asthma was significantly less likely among participants with Ascaris eggs (aOR = 0.43, p = .048) and Trichuris eggs (aOR = 0.36, p = .024). The findings of co-occurrent helminthiasis and allergic disorders in a population that has resided both in rural and peri-urban informal settlements both oppose and agree with two main notions of the hygiene hypothesis that (i) individuals residing in rural settings with poor sanitation and geohelminth infection are less prone to allergy, and (ii) helminth infections protect against allergy respectively. Further research is warranted.-
Related Research Outputs:
- Investment into eco-tourism projects: KwaZulu-Natal coastal belt: South Africa
- NASFAM funding proposal for the National AIDS Commission
- Trends and policy challenges in the rural economy: four provincial case studies
- Rural development in South Africa: tensions between democracy and traditional authority
- Living with rats
- The importance of indigenous knowledge in reducing poverty of rural Agrarian households
- Gender, development and transport in rural South Africa: methodological, policy and implementation challenges
- Rural municipality case studies: land reform, farm employment and livelihoods
- Rural development: strategies and challenges
- Don't underestimate cities' role in rural growth
- Outcome 7: vibrant, equitable and sustainable rural communities and food security for all
- Sustainable rural development: employment and household farming
- Urban and rural areas: allies not rivals
- Whither agrarian reform in South Africa?
- The influence of different helminth infection phenotypes on immune responses against HIV in co-infected adults in South Africa
- Technological initiatives for rural development: evidence from eight comprehensive rural development programme pilot sites
- Spatial mapping and analysis of integrated agricultural land use and infrastructure in Mhlontlo local municipality, Eastern Cape, South Africa
- Incomprehension follows the comprehensive rural development programme
- Reforming the land: agrarian reform projects missing pro-poor target
- The association between self-reported stigma and loss-to-follow up in treatment eligible HIV positive adults in rural Kwazulu-Natal, South Africa