The investigation of the use of Prealbumin as a tool for nutritional assessment in adults coinfected with HIV and intestinal Helminth parasites in KwaZulu-Natal, South Africa
OUTPUT TYPE: Journal Article
PUBLICATION YEAR: 2018
TITLE AUTHOR(S): B.T.Mkhize, M.Mabaso, S.Madurai, Z.L.Mkhize-Kwitshana
KEYWORDS: GEOHELMINTH INFECTIONS, HIV/AIDS, PREALBUMIN
DEPARTMENT: Public Health, Societies and Belonging (HSC)
Print: HSRC Library: shelf number 10475
HANDLE: 20.500.11910/12507
URI: http://hdl.handle.net/20.500.11910/12507
If you would like to obtain a copy of this Research Output, please contact Hanlie Baudin at researchoutputs@hsrc.ac.za.
Abstract
Serum prealbumin is considered to be as important as albumin in the nutritional status assessment. However, there is relatively little evidence of its advantage over the commonly used albumin. This study investigated the use of prealbumin compared to albumin as a marker of nutritional status in adults singly and dually infected with human immunodeficiency virus (HIV) and intestinal helminths, with or without inflammatory conditions, in different body mass index (BMI) categories. This cross-sectional study was conducted in a peri-urban setting in KwaZulu-Natal, South Africa. Multivariate multi-nominal logistic regression models were fitted to investigate the effect of prealbumin and albumin in nutritional assessment among HIV and helminth individuals with or without inflammation, indicated by elevated and normal C-reactive protein (CRP) levels. In normal CRP, albumin was significantly lower in unadjusted BMI [RRR = 0.8, p = 0.001] and in normal weight [RRR = 0.7, p = 0.003] and overweight [RRR = 0.5, p = 0.001] participants. In elevated CRP, albumin was significantly lower [RRR = 0.8, p = 0.050] and prealbumin was significantly higher in unadjusted BMI [RRR = 1.2, p = 0.034] and overweight [RRR = 1.4, p = 0.052] individuals. Te current study found that prealbumin can differentiate between inflammation-induced reduction of albumin and true malnutrition in adults singly or coinfected with HIV and intestinal helminths in the presence or absence of inflammation in various BMI categories.-
Related Research Outputs:
- The influence of different helminth infection phenotypes on immune responses against HIV in co-infected adults in South Africa
- Can deworming delay immunosuppression in HIV?
- The neglected triple disease burden and interaction of helminths, HIV and tuberculosis: an opportunity for integrated action in South Africa
- Proliferative capacity and cytokine production by cells of HIV-infected and uninfected adults with different helminth infection phenotypes in South Africa
- The interaction between HIV and intestinal Helminth parasites coinfection with nutrition among adults in KwaZulu-Natal, South Africa
- Helminthiasis: a systematic review of the immune interactions present in individuals coinfected with HIV and/or tuberculosis
- Time for the next steps
- Impacts and interventions: the HIV/AIDS epidemic and the children of South Africa
- Children and HIV/AIDS
- Impacts and interventions: the HIV/AIDS epidemic and the children of South Africa
- Managing chronic diseases in less developed countries: healthy teamworking and patient partnership are just as important as adequate funding
- Nelson Mandela/HSRC study of HIV/AIDS: South African national HIV prevalence, behavioural risks and mass media: household survey 2002
- Sickness, death and poverty - our bequest to orphans
- Sex & risk: facilitator's manual: an HIV/AIDS risk reduction programme for tertiary level students
- Sex & risk: student's workbook an HIV/AIDS risk reduction programme for tertiary level students
- HIV/AIDS and land: case studies from Kenya, Lesotho and South Africa
- The views of selected Government Departments on the need and use of HIV/AIDS indicators and potential impact of HIV/AIDS on their function
- Proposed indicators to monitor the social impact and other aspects of HIV/AIDS in South Africa
- Evaluation of the quality of care for sexually transmitted infections in primary health care centres in South Africa
- Geophagy and its association with geohelminth infection in rural schoolchildren from northern Kwazulu-Natal, South Africa