Haematological adverse effects associated with linezolid in patients with drug-resistant tuberculosis: an exploratory study
SOURCE: International Journal of Pharmacy Practice
OUTPUT TYPE: Journal Article
PUBLICATION YEAR: 2019
TITLE AUTHOR(S): G.Letswee, H.Kamau, R.Gaida, I.Trutor
KEYWORDS: DRUG RESISTANCE, TUBERCULOSIS
DEPARTMENT: Public Health, Societies and Belonging (HSC)
Print: HSRC Library: shelf number 10872
HANDLE: 20.500.11910/13965
URI: http://hdl.handle.net/20.500.11910/13965
OUTPUT TYPE: Journal Article
PUBLICATION YEAR: 2019
TITLE AUTHOR(S): G.Letswee, H.Kamau, R.Gaida, I.Trutor
KEYWORDS: DRUG RESISTANCE, TUBERCULOSIS
DEPARTMENT: Public Health, Societies and Belonging (HSC)
Print: HSRC Library: shelf number 10872
HANDLE: 20.500.11910/13965
URI: http://hdl.handle.net/20.500.11910/13965
If you would like to obtain a copy of this Research Output, please contact Hanlie Baudin at researchoutputs@hsrc.ac.za.
Abstract
The objectives of this study were to identify the incidence of haematological adverse effects associated with linezolid. Medical records of 27 hospitalised patients in South Africa with drug-resistant tuberculosis (DR-TB) and prescribed linezolid therapy were retrospectively reviewed. Approximately a quarter (n = 7) of patients experienced haematological adverse effects. These included anaemia (14.8%; n = 4), low haemoglobin (7.4%; n = 2) and macrocytosis (3.7%; n = 1). All patients who exhibited haematological adverse effects were living with HIV. The haematological effects of linezolid manifested in patients who were suffering from co-morbid HIV. Haematological monitoring should be done monthly in order to detect adverse effects timeously and intervene as appropriate.-
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